什么是子宫内膜容受性测定 (ERA)？
子宫内膜容受性测定 (ERA) 是一种分子水平测试，用于确定胚胎移植孕酮治疗的最佳时机。在先前的胚胎移植无效或出于其他原因的情况下，可以选择性地提供 ERA（例如，在胚胎数量较少的情况下）。
An ERA involves preparing the uterus using a combination of estrogen and progesterone, in an attempt to mimic the conditions for the actual embryo transfer as closely as possible. Typically, 5 days after initiating treatment with progesterone, an in office endometrial biopsy is performed. This involves a speculum exam (similar to a pap smear), with placement of a catheter (a thin straw) through the cervix and into the uterine cavity, in order to obtain a sample of the uterine lining (endometrial biopsy). RNA is then extracted from the endometrial biopsy, and a gene expression profile analysis (a study of which genes are turned on and off) is performed on the sample. This profile is then compared to a bank of reference profiles, and used to make adjustments to obtain the optimal timing of embryo transfer after progesterone administration start.
该测试确认了胚胎植入胚胎窗口的最佳时机。
