Controlled Ovarian Hyperstimulation (COH) at ICRM
Controlled ovarian hyperstimulation (COH) is a process in which fertility medications stimulate the ovaries to produce one or more ovulatory follicles. The goal of COH is to increase monthly fertility rates, with a focus on achieving a healthy singleton pregnancy. This approach is especially helpful for women with irregular periods or those who do not regularly ovulate, as it helps restore or induce ovulation.
At ICRM, we utilize controlled ovarian hyperstimulation to enhance fertility potential by encouraging the development of mature ovarian follicles, each containing an egg capable of fertilization.
How COH Works
Controlled ovarian hyperstimulation (COH) begins with taking fertility medications, either oral medication like clomiphene citrate or letrozole, and/or injectable fertility hormones like follicle-stimulating hormone (FSH), to stimulate follicles in the ovary. Each mature follicle contains one egg that is capable of being fertilized.
- In women who experience irregular periods or do not normally ovulate, the goal of COH is to induce the development of one mature follicle and restore normal ovulatory function.
- In women who have regular menses and ovulate each month, controlled ovarian hyperstimulation is used to “super ovulate,” in hopes of increasing pregnancy rates by producing 2-3 mature follicles per cycle.
- During treatment, ultrasound monitoring is performed regularly to ensure safe and effective stimulation, reducing the risk of ovarian hyperstimulation syndrome (OHSS).
Success with COH depends on individual factors, such as age and specific fertility diagnosis. It’s important to note that while the goal is to achieve a healthy singleton pregnancy, Multiple pregnancy rates account for 1-30% of these pregnancies, based on the age of the egg and the number of mature follicles obtained.
COH and IUI
In conjunction with COH, intrauterine insemination (IUI) is often recommended to improve success rates, especially for couples with unexplained infertility, mild to moderate endometriosis, or mild to moderate male factor infertility. If conception does not occur after 3 to 6 cycles of COH with IUI, a consultation is recommended to review potential causes and discuss proceeding to 体外受精 (IVF).
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