¿Qué es un ensayo de receptividad endometrial (ERA)?
Un ensayo de receptividad endometrial (ERA) es una prueba de nivel molecular que se utiliza para determinar el momento óptimo del tratamiento con progesterona para la transferencia de un embrión. Se puede ofrecer una ERA de forma electiva (por ejemplo, en casos con un número bajo de embriones), en situaciones en las que una transferencia de embriones previa no ha funcionado o por otras razones.
An ERA involves preparing the uterus using a combination of estrogen and progesterone, in an attempt to mimic the conditions for the actual embryo transfer as closely as possible. Typically, 5 days after initiating treatment with progesterone, an in office endometrial biopsy is performed. This involves a speculum exam (similar to a pap smear), with placement of a catheter (a thin straw) through the cervix and into the uterine cavity, in order to obtain a sample of the uterine lining (endometrial biopsy). RNA is then extracted from the endometrial biopsy, and a gene expression profile analysis (a study of which genes are turned on and off) is performed on the sample. This profile is then compared to a bank of reference profiles, and used to make adjustments to obtain the optimal timing of embryo transfer after progesterone administration start.
Esta prueba confirma el mejor momento para la ventana de implantación del embrión del embrión.
